CAROLINA: Where Now For DPP-4i´s and Sulfonylureas

CAROLINA is a large cardiovascular outcome trial assessing the cardiovascular safety of Linagliptin vs. the sulfonylureas Glimepiride in patients with type 2 diabetes. The study addresses a long-lasting discussion on the cardiovascular safety of sulfonylureas stemming from the UGDP trial in the 60´s which raised the concern of an increase in cardiovascular death in treated patients by sulfonylureas.

The present overview lecture will address the ongoing discussion on the safety of sulfonylureas and present data from the CAROLINA trial.